Psyched Wellness Announces Additional Positive Results From The 14-Day Oral Toxicity Study Of AME-1
Toronto, Ontario, Feb 3, 2022 – Psyched Wellness Ltd. (CSE:PSYC, OTCQB:PSYCF, FRANKFURT:5U9) (the “Company” or “Psyched”) a life sciences company focused on the production and distribution of artisanal functional and psychedelic mushrooms, is pleased to report additional positive findings from the preclinical 14-day oral toxicity study with Amanita Muscaria (AME-1), which was performed in conjunction with an analysis of its impact on gut epithelial cells.
The in vivo study via oral supplementation with AME-1 focused on the potential bioactive effects on the immune receptors Toll-like Receptor-2 (TLR-2) and Dectin-1, both found in gut epithelial cells, which play an important role in defensive immune system mechanisms against pathogens.
The 14-day oral in vivo study resulted in a dose-dependent increase in Toll-like-receptor-2 expression, while Dectin-1 did not have any change in cell surface expression under the same study conditions. The marginal increase of up to two-fold in the TLR-2 study suggests AME-1 could be a potential bioactive agent with possible immune-priming effects, which may be due to its ability to increase cell surface plasma membrane concentration content of TLR-2.
“The importance of these initial in vivo results indicate an innate immune-priming biological activity, potentially resulting in a more efficient response to an invading pathogen, thus promoting greater gut health and increased wellbeing of the individual. While we plan to investigate this further, this is another key finding in understanding the effects of AME-1 and provides more evidence of the potential natural health benefits of the extract,” said Brian Tancowny Scientific Advisor for Psyched Wellness.
Jeffrey Stevens, CEO of the Company, said, “These results are very encouraging from an R&D perspective for building more knowledge on our proprietary extract, AME-1. These findings advance our conviction that we are just scratching the surface when it comes to the potential health benefits of AME-1 beyond our initial product pipeline, which we are continuing to examine in detail.”