Psyched Wellness Amanita Muscaria Extract, AME-1, is Published in the Journal, Frontiers in Pharmacology

  • Amanita muscaria extract can positively modulate brain health

  • Amanita muscaria extract activates microglia which are the main form of active immunity in the central nervous system

  • Discovery of a high level of Trehalose, a sugar used in food, beauty and Pharmaceutical products

Toronto, Ontario--(Newsfile Corp May 2nd, 2023) - Psyched Wellness Ltd. (CSE: PSYC) (OTC Pink: DCNPF) (formerly Duncan Park Holdings Corporation) (the "Company" or "Psyched"), a life sciences company focused on the production and distribution of artisanal functional mushrooms, is pleased to announce that results from a recent scientific study, to be published in Frontiers in Pharmacology, show that Amanita muscaria extract activates human microglia, which play a key role in maintaining brain function.

The study, titled Amanita muscaria extract potentiates production of proinflammatory cytokines by dsRNA-activated human microglia” and conducted by the National Research Council of Canada (NRC), demonstrates that Amanita muscaria extract activates immune cells of the brain called microglia, which are resident macrophage cells that act as the first and main form of active immunity in the central nervous system. Using human microglia cells grown in lab cultures, the group has shown for the first time that Amanita muscaria activates these important brain immune cells to produce immune mediators which can mobilize other immune cells in the brain and alter the way in which neurons function. This is important as microglia cells are key cells involved in brain maintenance clearing the central nervous system (CNS) of plaques, damaged neurons, excess synapse, and infectious agents. Key areas of neuroinflammation and immune induced changes in the brain may be responsible for migraine, depression, and changes in sleep patterns.

This study shows for the first time how Amanita muscaria extract can positively modulate brain health. At the same time, Amanita muscaria extract can cause microglia to express important receptors on their surface that can help them interact with other brain cells. Using metabolite screening technology, the group also showed that Amanita muscaria extracts contain important metabolites such as trehalose, a sugar produced by some fungi and yeasts that is used as an ingredient in food, beauty products and some pharmaceutical products, which could be playing an important role in mediating the microglial inflammatory responses. Overall, this new study shows that Amanita muscaria may influence microglial function.

Frontiers in Pharmacology is the 3rd most-cited and 6th largest research publisher and open science platform. Their research journals are community-driven and peer-reviewed by editorial boards of over 202,000 top researchers. Featuring pioneering technology, artificial intelligence, and rigorous quality standards, our research articles have been viewed more than 1.9 billion times, reflecting the power of open research.

“The importance of this publication indicates for the first time that, under in vitro conditions, Amanita muscaria extract activates human microglia, which are immune cells in the brain. They are known as resident macrophages that act as the first and main form of the active immune defense system in the central nervous system. The potential priming effect results in a more efficient response of these cells to help maintain brain maintenance and thus sustainment of normal brain functions “says Brian Tancowny, Scientific Advisor for Psyched Wellness.

“The National Research Council of Canada based its research on our Company’s proprietary Amanita Muscaria extract, AME-1, and proved additional benefits of our effective supplement. This is another key finding of function and furthers our understanding of the effects of AME-1” says David Shisel, Chief Operations Officer for Psyched Wellness.